酶科学/Ub+1多克隆抗体/BML-PW9780-0025/25µ；L
商品编号：
BML-PW9780-0025
品牌：
enzolifesciences
市场价：
¥2000.00
美元价：
1200.00
产品分类：
特色ELISA试剂盒
公司分类：
Specialty_ELISA_kits
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product Specification:
| Alternative Name: | Ubiquitin+1 |
| Host: | Rabbit |
| Immunogen: | Synthetic peptide corresponding to aa 76-95 of human Ub+1. |
| UniProt ID: | P0CG47 (UBB), P0CG48 (UBC), P62979 (RPS27A), P62987 (UBA52) |
| Species reactivity: | Human |
| Applications: | IHC, WB |
| Recommended Dilutions/Conditions: | Western Blot (1:1,000) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Formulation: | Liquid. Antiserum containing 0.1% sodium azide. |
| Use/Stability: | Store unopened vial at -20°C until required for use. The use of high quality 'antiserum-grade' plastic or glass vials is recommended.. Dilute to working strength with phosphate buffered saline pH 7.2-7.4 and 1% normal goat serum (if a goat anti-rabbit IgG linker antibody is to be used). Store diluted antibody at 2-4°C (do not freeze) and use within 1 month. |
| Handling: | Do not freeze. After opening, prepare aliquots and store at -20°C. |
| Shipping: | Shipped on Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | Ub+1 is a novel form of ubiquitin that has been selectively observed in the brains of Alzheimer's patients, including those with nonfamilial Alzheimer's disease. Ub+1 is an efficient substrate for polyubiquitinylation in vitro and in transfected human cells. The resulting polyubiquitin chains are refractory to disassembly by deubiquitinating enzymes and potently inhibit the degradation of a polyubiquitinylated substrate by purified 26S proteasomes. Thus, expression of Ub+1 in aging brain could result in dominant inhibition of the Ub-proteasome system, leading to neuropathologic consequences. Expression of Ub+1 occurs through a phenomenon known as molecular misreading, in which non-DNA-encoded dinucleotide deletion(s) are found in mRNA within or adjacent to GAGAG motifs. A mechanism by which Ub+1 expression could lead to dominant inhibition of the Ub-proteasome system has been demonstrated. |
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Company Profile
Name:Enzo Life SciencesCategory:Corporation/Limited Liability CompanyTrade Category: ManufacturerRegistered Time: 1996Registered Capital: Above US$100 MillionLegal Representative:Employees:Address: TaksimWebsite: http://www.enzolifesciences.comProduct/Service: chemicals
Our breadth of scientific expertise coupled with unique technology platforms give us the flexibility to drive innovation throughout the entire research continuum. From life sciences research discovery efforts, through drug development, and into clinical research, our comprehensive range of products are designed to support your goals. When a standard catalog product does not meet your needs, talk to us about custom solutions; we can help
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