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Enzolifesciences/Shc polyclonal antibody/ALX-210-535-R100/100µl
Enzolifesciences/Shc polyclonal antibody/ALX-210-535-R100/100µl
商品编号：
ALX-210-535-R100
品牌：
enzolifesciences
市场价：
¥4080.00
美元价：
2448.00
产品分类：
外泌体研究
公司分类：
exosome_research
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product Specification:
| Alternative Name: | SH2 domain protein C1, Shc transforming protein 1, Shc1 |
| Host: | Rabbit |
| Immunogen: | Recombinant human Shc portion (aa 1180-1620). |
| UniProt ID: | P29353 |
| Species reactivity: | Human, Mouse Hamster |
| Specificity: | Recognizes p46shc, p52shc and p66shc isoforms of phosphorylated and unphosphorylated Shc. |
| Applications: | ELISA, IP, WB |
| Formulation: | Liquid. Neat serum containing 0.05% sodium azide. |
| Handling: | Avoid freeze/thaw cycles. |
| Shipping: | Shipped on Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | There are 3 alternatively spliced isoforms of the Shc adapter pro-tein: p46SHC, p52SHC and p66SHC, that link activated growth factor receptors to signalling pathway. Isoform p46SHC and p52SHC, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS com-plex and are implicated in mitogenic signalling. They function as initiators of the Ras signalling cascade in various non-neuronal systems. The isoform p66SHC does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. It acts as a downstream target of the tumor suppressor p53 and is indispen-sable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. |
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Company Profile
Name:Enzo Life SciencesCategory:Corporation/Limited Liability CompanyTrade Category: ManufacturerRegistered Time: 1996Registered Capital: Above US$100 MillionLegal Representative:Employees:Address: TaksimWebsite: http://www.enzolifesciences.comProduct/Service: chemicals
Our breadth of scientific expertise coupled with unique technology platforms give us the flexibility to drive innovation throughout the entire research continuum. From life sciences research discovery efforts, through drug development, and into clinical research, our comprehensive range of products are designed to support your goals. When a standard catalog product does not meet your needs, talk to us about custom solutions; we can help
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