当前位置：
首页
>
产品中心 >
exosome_research >
Enzolifesciences/Proteinase-activated receptor-4 (extracellular) polyclonal antibody/BML-SA652-0200/200µl
Enzolifesciences/Proteinase-activated receptor-4 (extracellular) polyclonal antibody/BML-SA652-0200/200µl
商品编号：
BML-SA652-0200
品牌：
enzolifesciences
市场价：
¥10580.00
美元价：
6348.00
产品分类：
外泌体研究
公司分类：
exosome_research
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product Specification:
| Alternative Name: | PAR-4 |
| Host: | Rabbit |
| Immunogen: | Synthetic peptide corresponding to aa 136-150 (with a C149S replacement) of human PAR-4 (proteinase-activated receptor-4). |
| UniProt ID: | Q96RI0 |
| Species reactivity: | Human, Rat |
| Applications: | Flow Cytometry, ICC, IHC, WB |
| Shipping: | Shipped on Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | PAR-4 belongs to a four member family of G protein-coupled receptors (PAR-1 to -4) that are activated as a result of proteolytic cleavage by certain serine proteases, hence their name. In this modality of activation, a specific proteinase cleaves the PAR receptor within a defined sequence in its extracellular N-terminal domain. This cleavage results in the creation of a new N-terminal sequence (tethered ligand), which subsequently binds to a site in the second extracellular loop of the same receptor. This binding results in the coupling of the receptor to G proteins and in the activation of several signal transduction pathways1-3 Different PARs are activated by different proteinases. PAR-4 is activated by both thrombin and trypsin whereas PAR-1 and PAR-3 are activated by thrombin and PAR-2 is activated by trypsin1-3. PAR-4 can be also cleaved and activated by other proteinases such as cathepsin G. The intracellular signaling mechanisms mediated by PAR-4 activation are not completely elucidated but they may involve calcium mobilization downstream of phospholipase C through the Gαq pathway1-3 Tissue distribution of PAR-4 is very broad with the highest expression levels found in lung, testis, pancreas and small intestine. In addition, PAR-4 expression was observed in platelets, megakaryocytes and leukocytes. Studies with platelets derived form PAR-4 knockout mice have established an essential role for PAR-4 in thrombin-induced platelet activation.PAR-4 is likely involved in other physiological functions such as regulation of gastrointestinal motility and regulation of vascular endothelial cell function1-3. |
品牌介绍
Product categoriesPharmaceuticals And Biochemic
CAS 6090-98-8
conduritol F
CAS 20544-37-0
2,4,8,10-Tetraoxa-3,
CAS 135564-23-7
Benzaldehyde, 4-amin
CAS 34169-62-5
2-Naphthalenesulfoni
CAS 6305-52-8
2-Butyldecahydronaph
CAS 10074-13-2
1,3-Benzenedimethane
CAS 84434-05-9
Acetic acid,2-[(9-ox
CAS 104748-51-8
Avilamycin K
CAS 5539-08-2
Ergoline-8-carboxyli
CAS 1242-56-4
Androst-1-en-3-one,1
CAS 52978-30-0
(1R,2R,3E,5E,15E,17E
CAS 24471-48-5
2-Pyrenemethanol
CAS 39325-01-4
Picibanil
CAS 244290-68-4
Quinolinium, 7-[(die
CAS 80584-90-3
1H-Benzotriazole-1-m
CAS 65193-87-5
Butanoic acid, 3-oxo
CAS 3563-92-6
Zylofuramine
CAS 24979-74-6
Phenol,4-ethenyl-, p
CAS 1067-48-7
1-Pentanamine, 5-(tr
CAS 62886-59-3
Sephadex-CM C-25,ion
View all products
Company Profile
Name:Enzo Life SciencesCategory:Corporation/Limited Liability CompanyTrade Category: ManufacturerRegistered Time: 1996Registered Capital: Above US$100 MillionLegal Representative:Employees:Address: TaksimWebsite: http://www.enzolifesciences.comProduct/Service: chemicals
Our breadth of scientific expertise coupled with unique technology platforms give us the flexibility to drive innovation throughout the entire research continuum. From life sciences research discovery efforts, through drug development, and into clinical research, our comprehensive range of products are designed to support your goals. When a standard catalog product does not meet your needs, talk to us about custom solutions; we can help
品牌分类
抗体
联络我们
