酶学/蛋白酶体激活剂11S和γ；亚单位多克隆抗体/BML-PW8190-0025/25µ；L
商品编号：
BML-PW8190-0025
品牌：
enzolifesciences
市场价：
¥2540.00
美元价：
1524.00
产品分类：
外泌体研究
公司分类：
exosome_research
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product Specification:
| Alternative Name: | Proteasome activator complex subunit 3, PA28γ |
| Host: | Rabbit |
| Immunogen: | Synthetic peptide corresponding to aa 70-85 of human and mouse Ki autoantigen/PA28γ. |
| UniProt ID: | P61289 (human), P61290 (mouse) |
| Species reactivity: | Human, Mouse |
| Specificity: | Recognizes the γ subunit of proteasome activator 11S. |
| Applications: | IHC, WB |
| Application Notes: | Detects a band of ~31kDa by Western blot. |
| Formulation: | Liquid. Antiserum containing 10mM sodium azide. |
| Use/Stability: | Dilute with PBS, pH 7.2-7.4 containing 1% normal goat serum (if a goat anti-rabbit IgG linker antibody is to be used). Store diluted antibody at +4°C (do not freeze) and use within 1 month. |
| Handling: | Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C. |
| Shipping: | Shipped on Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | The proteasome is widely recognised as the central enzyme of non-lysosomal protein degradation. It is responsible for intracellular protein turnover and it is also critically involved in many regulatory processes and, in higher eukaryotes, in antigen processing. The 26S proteasome is the key enzyme of the ubiquitin/ATP-dependent pathway of protein degradation. The catalytic core of this unusually large (2000kDa, 450Å in length) complex is formed by the 20S proteasome, a barrel shaped structure shown by electron microscopy to comprise of four rings each containing seven subunits. 20S Proteasomes degrade only unfolded proteins in an energy-independent manner, whereas 26S proteasomes degrade native and ubiquitinylated proteins in an ATP-dependent manner. The native protein substrates are recognised by subunits, some with ATP binding sites, of the outer 19S caps of the 26S proteasome.A second activator which can associate with the 20S proteasome in the absence of ATP is known as PA28 or the 11S regulator. The pure PA28 activator is a complex of two alternating subunits, PA28α and PA28β, which share approximately 50% homology but also show considerable similarity (30-40%) to a nuclear protein of unknown function, the Ki autoantigen (now referred to as PA28γ). These subunits, with an apparent relative molecular weight of approximately 29kDa, form ringlike heteromeric complexes of ~200kDa possibly with an α3β3 stoichiometry. Electron microscopic studies have shown PA28 to be a ring shaped particle which, like the 19S, caps the 20S proteasome, by binding to the α-rings, at both or either end. The complex may, however, be readily dissociated. The finding that PA28 modulates the proteasome-catalysed production of antigenic peptides presented to the immune system on MHC class I molecules indicates a cellular function of this activator in antigen processing. |
品牌介绍
Product categoriesPharmaceuticals And Biochemic
CAS 6090-98-8
conduritol F
CAS 20544-37-0
2,4,8,10-Tetraoxa-3,
CAS 135564-23-7
Benzaldehyde, 4-amin
CAS 34169-62-5
2-Naphthalenesulfoni
CAS 6305-52-8
2-Butyldecahydronaph
CAS 10074-13-2
1,3-Benzenedimethane
CAS 84434-05-9
Acetic acid,2-[(9-ox
CAS 104748-51-8
Avilamycin K
CAS 5539-08-2
Ergoline-8-carboxyli
CAS 1242-56-4
Androst-1-en-3-one,1
CAS 52978-30-0
(1R,2R,3E,5E,15E,17E
CAS 24471-48-5
2-Pyrenemethanol
CAS 39325-01-4
Picibanil
CAS 244290-68-4
Quinolinium, 7-[(die
CAS 80584-90-3
1H-Benzotriazole-1-m
CAS 65193-87-5
Butanoic acid, 3-oxo
CAS 3563-92-6
Zylofuramine
CAS 24979-74-6
Phenol,4-ethenyl-, p
CAS 1067-48-7
1-Pentanamine, 5-(tr
CAS 62886-59-3
Sephadex-CM C-25,ion
View all products
Company Profile
Name:Enzo Life SciencesCategory:Corporation/Limited Liability CompanyTrade Category: ManufacturerRegistered Time: 1996Registered Capital: Above US$100 MillionLegal Representative:Employees:Address: TaksimWebsite: http://www.enzolifesciences.comProduct/Service: chemicals
Our breadth of scientific expertise coupled with unique technology platforms give us the flexibility to drive innovation throughout the entire research continuum. From life sciences research discovery efforts, through drug development, and into clinical research, our comprehensive range of products are designed to support your goals. When a standard catalog product does not meet your needs, talk to us about custom solutions; we can help
品牌分类
抗体
联络我们
