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Enzolifesciences/PDI monoclonal antibody (RL90)/ALX-804-012-R100/100µl
Enzolifesciences/PDI monoclonal antibody (RL90)/ALX-804-012-R100/100µl
商品编号：
ALX-804-012-R100
品牌：
enzolifesciences
市场价：
¥12300.00
美元价：
7380.00
产品分类：
外泌体研究
公司分类：
exosome_research
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product Specification:
| Alternative Name: | Protein disulfide-isomerase |
| Clone: | RL90 |
| Host: | Mouse |
| Isotype: | IgG2a |
| Immunogen: | Purified rat PDI (protein disulfide-isomerase). |
| UniProt ID: | P04785 |
| Species reactivity: | Human, Mouse, Rat Hamster, Porcine |
| Applications: | Flow Cytometry, ICC, IHC (FS), IHC (PS), IP, WB, FUNC |
| Recommended Dilutions/Conditions: | Immunocytochemistry (1:100) Immunohistochemistry (frozen sections, 1:100) Western Blot (1:1,000) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of ~59kDa (rat liver extract) or ~61kDa (human liver extract) by Western blot. |
| Purity Detail: | Protein A-affinity purified. |
| Formulation: | Liquid. Purified antibody containing 1mg/ml BSA and 0.05% sodium azide. |
| Handling: | Avoid freeze/thaw cycles. |
| Shipping: | Shipped on Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | The three dimensional structure of many extracellular proteins is stabilized by the formation of disulphide bonds. Studies suggest that a microsomal enzyme known as Protein Disulphide-Isomerase (PDI) is involved in disulphide-bond formation and isomerization, as well as the reduction of disulphide bonds in proteins. PDI, which catalyses disulphide interchange between thiols and protein dilsulphides, has also been referred to as thiol:protein-disulphide oxidoreductase and as glutathione:insulin transhydrogenase because of its role in reduction of disulphide bonds. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the carboxy-terminus of PDI and other soluble endoplasmic reticulum (ER) resident proteins including the 78 and 94 kDa glucose regulated proteins (GRP78 and GRP94 respectively). The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor. |
| Technical Info/Product Notes: | Immunohistochemical staining of PDI in rat intestine with Prod. No. ALX-804-012 yields a pattern consistent with cytoplasmic staining. In immunoprecipitation procedures, Prod. No. ALX-804-012 has been shown to inhibit the activity of PDI in vitro. Prod. No. ALX-804-012 has also been found to inhibit disulfide bond reduction of the HIV protein, gp120, at the cell surface of CHO cells and human lymphoid cells. |
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Company Profile
Name:Enzo Life SciencesCategory:Corporation/Limited Liability CompanyTrade Category: ManufacturerRegistered Time: 1996Registered Capital: Above US$100 MillionLegal Representative:Employees:Address: TaksimWebsite: http://www.enzolifesciences.comProduct/Service: chemicals
Our breadth of scientific expertise coupled with unique technology platforms give us the flexibility to drive innovation throughout the entire research continuum. From life sciences research discovery efforts, through drug development, and into clinical research, our comprehensive range of products are designed to support your goals. When a standard catalog product does not meet your needs, talk to us about custom solutions; we can help
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