酶科学/Orai1（细胞外）（人类）多克隆抗体/BML-SA674-0200/200µ；L
商品编号：
BML-SA674-0200
品牌：
enzolifesciences
市场价：
¥10620.00
美元价：
6372.00
产品分类：
外泌体研究
公司分类：
exosome_research
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product Specification:
| Alternative Name: | Calcium release-activated calcium channel protein 1, Transmembrane protein 142A |
| Host: | Rabbit |
| Immunogen: | Synthetic peptide corresponding to aa 203-214 (K203KQPGQPRPTSK214) of human Orai1. |
| UniProt ID: | Q96D31 |
| Species reactivity: | Human |
| Crossreactivity: | Does not cross-react with mouse or rat Orai1. |
| Applications: | Flow Cytometry, WB |
| Recommended Dilutions/Conditions: | Western Blot (1:200) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Blocking Peptide: | 40μg included. Lyophilized. Reconstitute with 100μl distilled water. |
| Purity Detail: | Affinity purified. |
| Formulation: | Lyophilized from PBS, pH 7.4, containing 1% BSA and 0.05% sodium azide. |
| Reconstitution: | Reconstitute with 50μl or 200μl distilled water. Further dilutions should be made with medium containing a carrier protein such as 1% BSA. |
| Use/Stability: | The antibody solution can be stored at +4°C for up to 2 weeks. |
| Handling: | Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C. |
| Shipping: | Shipped on Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | Cytosolic calcium (Ca2+) has long been known to act as a key second messenger in many intracellular pathways including synaptic transmission, muscle contraction, hormonal secretion, cell growth and proliferation. The mechanism controlling intracellular Ca2+ level influx either by the calcium-release-activated Ca2+ channels (CRAC), or from intracellular stores, has become of great interest to researchers. Several key players of the store operated complex have been identified. Orai1 (also known as CRACM1) acts as the store operated calcium channel (SOC) and STIM1, which acts as the endoplasmic reticulum Ca2+ sensor. The formation of functional channels by Orai1 requires the presence of both Orai1 and STIM1 proteins working as a complex that involves the co-clustering of Orai1 on the plasma membrane with STIM1 on the endoplasmic reticulum. |
| Technical Info/Product Notes: | Preadsorption control: 1µg peptide per 1µg antibody. Prepare 2 tubes. In the first, dilute the necessary amount of antibody in 200-500µl of PBS, 1% BSA and 0.025% sodium azide. Prepare the second tube identically to the first with the addition of the appropriate amount of peptide. Incubate at room temperature for 1 hr. Centrifuge both tubes at 10,000Xg for 5 min. Use the supernatants from tubes 1 and 2 for parallel experiments. |
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Company Profile
Name:Enzo Life SciencesCategory:Corporation/Limited Liability CompanyTrade Category: ManufacturerRegistered Time: 1996Registered Capital: Above US$100 MillionLegal Representative:Employees:Address: TaksimWebsite: http://www.enzolifesciences.comProduct/Service: chemicals
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