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Enzolifesciences/HSP90 Co-chaperone monoclonal antibody (JJ3)/ALX-804-023-R100/100µl
Enzolifesciences/HSP90 Co-chaperone monoclonal antibody (JJ3)/ALX-804-023-R100/100µl
商品编号：
ALX-804-023-R100
品牌：
enzolifesciences
市场价：
¥11800.00
美元价：
7080.00
产品分类：
外泌体研究
公司分类：
exosome_research
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product Specification:
| Alternative Name: | Progesterone receptor complex p23, Telomerase-binding protein p23 |
| Clone: | JJ3 |
| Host: | Mouse |
| Isotype: | IgG2a |
| Immunogen: | Recombinant human HSP90 Co-chaperone. |
| UniProt ID: | Q15185 |
| Species reactivity: | Human, Mouse Chicken, Guinea pig, Rabbit |
| Applications: | ICC, IP, WB |
| Recommended Dilutions/Conditions: | Immunoprecipitation (use on free or complexed HSP90 Co-chaperone) Western Blot (1:1,000) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of ~23kDa by Western blot. |
| Formulation: | Liquid. Ascites diluted in PBS containing 0.05% sodium azide. |
| Handling: | Avoid freeze/thaw cycles. |
| Shipping: | Shipped on Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Prior to activation, steroid receptors associate with a number of different proteins in both a stable and transient fashion. Steroid receptor complex proteins include heat shock proteins (HSP70 and HSP90), immunosuppressant binding proteins called immunophilins (the FK506 binding proteins, FKBP52 & FKBP54 and the cyclosporin binding protein, CyP-40) and at least three other proteins termed p23, p60 and p48. p23 along with HSP70, HSP90 and p60, combine with progesterone receptor (PR) as members of a transient intermediate complex. Cloned human p23 encodes a protein of 160 aa that is highly conserved between species and shows no homology to previously identified proteins. p23 is a highly acidic phosphoprotein with an aspartic acid-rich C-terminal domain and multiple potential phosphorylation sites. In vitro studies have suggested that p23 binds to HSP90 and is necessary for the binding of HSP90 and CyP-40 to PR. While neither its exact function nor mechanism of action have been identified, p23 appears to be an important factor in PR function. |
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Company Profile
Name:Enzo Life SciencesCategory:Corporation/Limited Liability CompanyTrade Category: ManufacturerRegistered Time: 1996Registered Capital: Above US$100 MillionLegal Representative:Employees:Address: TaksimWebsite: http://www.enzolifesciences.comProduct/Service: chemicals
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