Enzolifesciences/HCN4 polyclonal antibody/BML-SA600-0050/50µl
商品编号：
BML-SA600-0050
品牌：
enzolifesciences
市场价：
¥6200.00
美元价：
3720.00
产品分类：
外泌体研究
公司分类：
exosome_research
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product Specification:
| Alternative Name: | Hyperpolarization-activated cyclic nucleotide-gated potassium channel 4 |
| Host: | Rabbit |
| Immunogen: | Recombinant human HCN4 (aa 119-155) |
| UniProt ID: | Q9Y3Q4 |
| Species reactivity: | Mouse, Rat |
| Applications: | IHC, WB |
| Formulation: | Lyophilized from PBS, pH 7.4, 1% BSA and 0.05% sodium azide. |
| Shipping: | Shipped on Dry Ice |
| Long Term Storage: | -80°C |
| Scientific Background: | Hyperpolarization-activated cation currents (Ih) appear in the heart and the brain and play a crucial role in controlling electrical pacemaker activity, contributing to biological processes such as heartbeat, sleep-wake cycle and synaptic plasticity. The Ih currents are generated by the Hyperpolarization-activated Cyclic Nucleotide-gated channel family (HCN), which comprises four homologous members, HCN1-4. Each HCN subunit consists of six transmembrane (TM) domains, a pore region between TM5-TM6 and a cyclic nucleotide binding domain in the cytoplasmic C-terminus. The HCN subunits can form functional homomers and can also co-assemble into functional heteromers. The channels are closely related to each other and are about 60% homologous. However, they differ from each other in their cytoplasmic N- and the C-termini. HCN1-4 differ in their speed of activation and the extent to which they are modulated by cAMP. HCN1 is the fastest channel, followed by HCN2, HCN3 and HCN4. This family of channels has been implicated in an alternative mechanism for chronic pain. |
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Company Profile
Name:Enzo Life SciencesCategory:Corporation/Limited Liability CompanyTrade Category: ManufacturerRegistered Time: 1996Registered Capital: Above US$100 MillionLegal Representative:Employees:Address: TaksimWebsite: http://www.enzolifesciences.comProduct/Service: chemicals
Our breadth of scientific expertise coupled with unique technology platforms give us the flexibility to drive innovation throughout the entire research continuum. From life sciences research discovery efforts, through drug development, and into clinical research, our comprehensive range of products are designed to support your goals. When a standard catalog product does not meet your needs, talk to us about custom solutions; we can help
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