当前位置：
首页
>
产品中心 >
exosome_research >
Enzolifesciences/Grp94 monoclonal antibody (9G10) (PE conjugate)/ADI-SPA-850PE-D/50µg
Enzolifesciences/Grp94 monoclonal antibody (9G10) (PE conjugate)/ADI-SPA-850PE-D/50µg
商品编号：
ADI-SPA-850PE-D
品牌：
enzolifesciences
市场价：
¥4300.00
美元价：
2580.00
产品分类：
外泌体研究
公司分类：
exosome_research
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product Specification:
| Alternative Name: | Endoplasmin, Tra1, Hsp90B1, Gp96 |
| Clone: | 9G10 |
| Host: | Rat |
| Isotype: | IgG2a |
| Immunogen: | Native chicken Grp94. |
| UniProt ID: | P08110 |
| GenBank ID: | M14772 |
| Species reactivity: | Human, Mouse, Rat Bovine, Chicken, Dog, Guinea pig, Hamster, Monkey, Porcine, Rabbit, Sheep, Xenopus |
| Applications: | Flow Cytometry |
| Recommended Dilutions/Conditions: | Flow Cytometry (1:100) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of ~94kDa by Western blot. |
| Purity Detail: | Protein G affinity purified. |
| Formulation: | Liquid. In PBS, pH 7.2, containing 0.09% sodium azide. |
| Handling: | Avoid vigorous centrifugation and vortexing. Do not freeze. Protect from light. |
| Shipping: | Blue Ice Not Frozen |
| Long Term Storage: | +4°C |
| Scientific Background: | Glucose-regulated protein 94 (Grp94, gp96), an abundant resident endoplasmic reticulum (ER) lumenal stress protein, belongs to the Hsp90 family of molecular chaperones along with cytosolic Hsp90. Grp94 and such other resident soluble proteins of the ER as the Ca 2+ binding protein subfamily (CaBP, CaBPI, CaBP2 and calreticulin) possess the C-terminal tetrapeptide Lys-Asp-Glu-Leu (KDEL), a sorting signal considered responsible for the retention of these proteins in the pre-Golgi compartments. Stress conditions such as glucose starvation and heat shock which promote protein misfolding or unfolding increase Grp94 expression. In addition to a homeostatic role in protein folding and assembly, Grp94 can function in the intracellular trafficking of peptides from the extracellular space to the MHC class I antigen processing pathway of antigen presentation cells. Grp94 and Hsp90 share high sequence identity and apparently identical adenosine nucleotide dependent modes of regulation, although previous data suggests that Hsp90 and Grp94 may differ in their nucleotide binding properties. The N-terminal domain of eukaryotic Hsp90 proteins contains a conserved adenosine nucleotide binding pocket which also serves as the binding site for the Hsp90 inhibitors geldanamycin and radicicol. However, the molecular basis for adenosine nucleotide-dependent regulation of Grp94 remains unclear. Data supports a ligand dependent regulation of Grp94 function, and suggests a model whereby Grp94 function is regulated through a ligand -dependent conversion of Grp94 from an inactive to an active conformation. |
品牌介绍
Product categoriesPharmaceuticals And Biochemic
CAS 6090-98-8
conduritol F
CAS 20544-37-0
2,4,8,10-Tetraoxa-3,
CAS 135564-23-7
Benzaldehyde, 4-amin
CAS 34169-62-5
2-Naphthalenesulfoni
CAS 6305-52-8
2-Butyldecahydronaph
CAS 10074-13-2
1,3-Benzenedimethane
CAS 84434-05-9
Acetic acid,2-[(9-ox
CAS 104748-51-8
Avilamycin K
CAS 5539-08-2
Ergoline-8-carboxyli
CAS 1242-56-4
Androst-1-en-3-one,1
CAS 52978-30-0
(1R,2R,3E,5E,15E,17E
CAS 24471-48-5
2-Pyrenemethanol
CAS 39325-01-4
Picibanil
CAS 244290-68-4
Quinolinium, 7-[(die
CAS 80584-90-3
1H-Benzotriazole-1-m
CAS 65193-87-5
Butanoic acid, 3-oxo
CAS 3563-92-6
Zylofuramine
CAS 24979-74-6
Phenol,4-ethenyl-, p
CAS 1067-48-7
1-Pentanamine, 5-(tr
CAS 62886-59-3
Sephadex-CM C-25,ion
View all products
Company Profile
Name:Enzo Life SciencesCategory:Corporation/Limited Liability CompanyTrade Category: ManufacturerRegistered Time: 1996Registered Capital: Above US$100 MillionLegal Representative:Employees:Address: TaksimWebsite: http://www.enzolifesciences.comProduct/Service: chemicals
Our breadth of scientific expertise coupled with unique technology platforms give us the flexibility to drive innovation throughout the entire research continuum. From life sciences research discovery efforts, through drug development, and into clinical research, our comprehensive range of products are designed to support your goals. When a standard catalog product does not meet your needs, talk to us about custom solutions; we can help
品牌分类
抗体
联络我们
