4000-520-616
欢迎来到免疫在线!(蚂蚁淘生物旗下平台)  请登录 |  免费注册 |  询价篮
主营:主营:基因诊断
咨询热线电话
4000-520-616
当前位置: 首页 > 产品中心 > exosome_research > Enzolifesciences/Glutathione S-transferase-Pi monoclonal antibody (USal-hGST-Pi-McAb-1)/ALX-804-510-C100/100µg
商品详细Enzolifesciences/Glutathione S-transferase-Pi monoclonal antibody (USal-hGST-Pi-McAb-1)/ALX-804-510-C100/100µg
Enzolifesciences/Glutathione S-transferase-Pi monoclonal antibody (USal-hGST-Pi-McAb-1)/ALX-804-510-C100/100µg
Enzolifesciences/Glutathione S-transferase-Pi monoclonal antibody (USal-hGST-Pi-McAb-1)/ALX-804-510-C100/100µg
商品编号: ALX-804-510-C100
品牌: enzolifesciences
市场价: ¥5640.00
美元价: 3384.00
产地: 美国(厂家直采)
公司:
产品分类: 外泌体研究
公司分类: exosome_research
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Product Specification:

Alternative Name:GST-π, GST-P, Glutathione S-transferase P, GSTP1
 
Clone:USal-hGST-Pi-McAb-1
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Recombinant human placenta GST-Pi (glutathione S-transferase-Pi).
 
UniProt ID:P09211
 
Species reactivity:Human, Rat
Leishmania
 
Crossreactivity:Does not cross-react with human or rat class alpha GST.
 
Applications:IHC (FS), WB
 
Recommended Dilutions/Conditions:Immunohistochemistry (frozen sections, 1:100)
Western Blot (1:150-1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Positive Control:Rat hepatocarcinoma can be used as positive control.
 
Purity Detail:Protein G-affinity purified.
 
Formulation:Liquid. Contains 100nM sodium azide and 0.7% BSA.
 
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:The GST Family
Glutathione S-transferases (GSTs) are a large multigen family of multifunctional enzymes, which play an important role in detoxification of potentially genotoxic chemicals, by catalyzing the conjugation of glutathione to a large number of hydrophobic and electrophilic compounds, including carcinogens. They also bind to a variety of nonsubstrate ligands. The GSTs are widely distributed in mammalian species and can be grouped into four classes, based on their biochemical, immunological and structural properties: alpha, mu, pi and theta.

GSTs are dimeric, mainly cytosolic, enzymes that have extensive ligand binding properties in addition to their catalytic role in detoxification. A separate microsomal class of GSTs exists which is quite distinct from the cytosolic GSTs, and is designated as "membrane-associated proteins in eicosanoid and glutathione metabolism" (MAPEG). The N-terminal region tends to be better conserved within classes as it includes an important part of the active site.

GSTs are believed to play a role in cancer prevention, as the electrophilic compounds that are conjugated to glutathione could otherwise react with and modify cellular components such as DNA, thereby initiating carcinogenesis. On the other hand, GSTs might detoxify chemotherapeutic drugs in cancer cells, thus contributing to drug resistance.
In summary, GSTs are a group of enzymes which are centrally involved in drug metabolism and detoxification. Because of their role in detoxification, they have been implicated in drug sensitivity and resistance. They may also influence mutagenesis and carcinogenesis and thus, increased GST activity may become a useful cancer marker.
Since many GST genes are polymorphic, there has been considerable interest in determining whether particular allelic variants are also associated with an increase of risk for certain diseases.

Glutathione S-transferase-Pi
The GST-Pi class (phase II detoxification enzymes) is the most abundant of the human glutathione S-transferases family, a major group of detoxification enzymes and widely distributed in the human body.
In normal human tissues, the enzymes protect cells against reactions with glutathione and reactive oxygen species by reducing organic hydroperoxides via gluthathione peroxidase activity.
The role of GST-Pi in tumor growth and progression is less well known. It is reported to be variably expressed in breast cancer and is associated with estrogen receptor levels expressed by the tumor. Down-regulation of GST-Pi activity in a study done on a T cell line appears to favor apoptosis and inhibition of GST-Pi function induces apoptosis in rat hepatoma cells.
The importance in cancer research is clear, as GST-Pi has been implicated in protection against apoptosis and also suggested to have a role in jun kinase inhibition.
The majority of human tumor cell lines express significant amounts of class pi GST, which is why it is being investigated as a potential marker for various types of cancer. GST-Pi is thought to be associated with increased resistance to anticancer drugs. GST-Pi expression is under investigation as a prognostic indicator for resistance to chemotherapy and a marker of treatment resistance.

 
品牌介绍
Product categoriesPharmaceuticals And Biochemic CAS 6090-98-8 conduritol F CAS 20544-37-0 2,4,8,10-Tetraoxa-3, CAS 135564-23-7 Benzaldehyde, 4-amin CAS 34169-62-5 2-Naphthalenesulfoni CAS 6305-52-8 2-Butyldecahydronaph CAS 10074-13-2 1,3-Benzenedimethane CAS 84434-05-9 Acetic acid,2-[(9-ox CAS 104748-51-8 Avilamycin K CAS 5539-08-2 Ergoline-8-carboxyli CAS 1242-56-4 Androst-1-en-3-one,1 CAS 52978-30-0 (1R,2R,3E,5E,15E,17E CAS 24471-48-5 2-Pyrenemethanol CAS 39325-01-4 Picibanil CAS 244290-68-4 Quinolinium, 7-[(die CAS 80584-90-3 1H-Benzotriazole-1-m CAS 65193-87-5 Butanoic acid, 3-oxo CAS 3563-92-6 Zylofuramine CAS 24979-74-6 Phenol,4-ethenyl-, p CAS 1067-48-7 1-Pentanamine, 5-(tr CAS 62886-59-3 Sephadex-CM C-25,ion View all products Company Profile Name:Enzo Life SciencesCategory:Corporation/Limited Liability CompanyTrade Category: ManufacturerRegistered Time: 1996Registered Capital: Above US$100 MillionLegal Representative:Employees:Address: TaksimWebsite: http://www.enzolifesciences.comProduct/Service: chemicals Our breadth of scientific expertise coupled with unique technology platforms give us the flexibility to drive innovation throughout the entire research continuum. From life sciences research discovery efforts, through drug development, and into clinical research, our comprehensive range of products are designed to support your goals. When a standard catalog product does not meet your needs, talk to us about custom solutions; we can help
品牌分类
抗体
联络我们
服务热线:4000-520-616
(限工作日9:00-18:00)
QQ :1570468124
手机:18915418616