Enzolifesciences/α Fodrin monoclonal antibody (AA6)/BML-FG6090-0100/100µl-免疫在线蚂蚁淘旗下平台

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商品详细Enzolifesciences/α Fodrin monoclonal antibody (AA6)/BML-FG6090-0100/100µl

Enzolifesciences/α Fodrin monoclonal antibody (AA6)/BML-FG6090-0100/100µl

商品编号： BML-FG6090-0100

品牌： enzolifesciences

市场价： ¥4520.00

美元价： 2712.00

产地：美国(厂家直采)

公司：

产品分类：外泌体研究

公司分类： exosome_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Product Specification:

Alternative Name:	αII-spectrin

Clone:	AA6

Host:	Mouse

Isotype:	IgG1

Immunogen:	Chicken blood cell membranes following hypotonic lysis and mechanical enucleation.

UniProt ID:	P07751

Species reactivity:	Chicken, Mammalian

Applications:	IHC, WB

Purity Detail:	Partially purified.

Formulation:	Liquid. In PBS containing 1.0% BSA and 0.09% sodium azide.

Use/Stability:	Store unopened vial at -20°C until required for use. AVOID REPEATED FREEZE-THAW CYCLES. Aliquot undiluted antibody into smaller volumes (not less than 10μL) prior to freezing if appropriate. The use of high quality ‘antiserum-grade’ plastic or glass vials is recommended. Store diluted antibody at 2-4°C (do not freeze) and use within 1 month. Dilute to working strength with 50mM Tris-HCl buffer (pH 7.6) containing 1.5% sodium chloride and 1% normal goat serum (if a goat anti-mouse IgG linker antibody is to be used).

Shipping:	Shipped on Blue Ice

Long Term Storage:	-20°C

Scientific Background:	Fodrin, also referred to as non-erythroid (αII-; brain) spectrin, is a tetrameric (αγ)2 actin-binding, fibrous protein, widely distributed in vertebrates, which forms part of the sub-membranous cytoskeleton within many cell types including neurons, and is particularly abundant with axons. The α-subunits of fodrins and spectrin are highly conserved phylogenetically, with the exception of human α-fodrin, which shares only 55-59% homology with erythroid-specific α-spectrins. The β-subunits of spectrin (and γ-subunits of fodrins) are species specific. The interleukin-1 converting enzyme (ICE) family of proteases has been implicated as important effectors of the apoptotic pathway, perhaps acting hierarchically in a protease cascade. Neuronal fodrin is known to be cleaved by calpain following ischaemic insult and it has been proposed that calpain and an unidentified protease play a role in the onset of neuronal death following transient forebrain ischaemia. Recently, an ICE-like protease has been implicated in the early cleavage of fodrin, producing a 150kDa fragment, proximal to CPP32 in Fas-induced and C₂-ceramide mediated apoptosis. A cleavage product of α-fodrin has been proposed as a candidate autoantigen in primary Sjögren’s syndrome and α-fodrin has been shown to be the source of a so-called ‘inhibitory protein factor’ family, members of which have been shown to inhibit both GABA and ATP-dependent glutamate uptake into purified synaptic vesicles.

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Product categoriesPharmaceuticals And Biochemic CAS 6090-98-8 conduritol F

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