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Enzolifesciences/DR6 (human) monoclonal antibody (Luke-1)/ALX-804-150-C100/100µg
Enzolifesciences/DR6 (human) monoclonal antibody (Luke-1)/ALX-804-150-C100/100µg
商品编号：
ALX-804-150-C100
品牌：
enzolifesciences
市场价：
¥7020.00
美元价：
4212.00
产品分类：
外泌体研究
公司分类：
exosome_research
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product Specification:
| Alternative Name: | Death receptor-6, TNFRSF 21 |
| Clone: | Luke-1 |
| Host: | Rat |
| Isotype: | IgG2a |
| Immunogen: | Recombinant human DR6 (death receptor-6) (aa 42-335) (Prod. No. ALX-522-019). |
| UniProt ID: | O75509 |
| Source: | Purified from concentrated hybridoma tissue culture supernatant. |
| Species reactivity: | Human |
| Applications: | Flow Cytometry |
| Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
| Use/Stability: | Stable for at least 1 year after receipt when stored as recommended. |
| Handling: | Avoid freeze/thaw cycles. |
| Shipping: | Shipped on Blue Ice |
| Short Term Storage: | +4°C |
| Long Term Storage: | -20°C |
| Scientific Background: | Apoptosis is induced by certain cytokines including TNF and Fas ligand (CD95L) of the TNF family through their death domain containing receptors, TNF-R1 and Fas (CD95). Several death receptors including DR3, TRAIL-R1, and TRAIL-R2 were identified. A death domain containing receptor in the TNF-R family was cloned and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-κB and JNK. DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified yet. T cells from DR6-deficient mice showed preference toward Th2 differentiation in vitro, suggesting that DR6, working through JNK functions to attenuate the Th2 response. Other studies of DR6-targeted mutant mice demonstrated that DR6 functions as a regulatory receptor for mediating CD4(+) T cell activation and maintaining proper immune responses. |
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Company Profile
Name:Enzo Life SciencesCategory:Corporation/Limited Liability CompanyTrade Category: ManufacturerRegistered Time: 1996Registered Capital: Above US$100 MillionLegal Representative:Employees:Address: TaksimWebsite: http://www.enzolifesciences.comProduct/Service: chemicals
Our breadth of scientific expertise coupled with unique technology platforms give us the flexibility to drive innovation throughout the entire research continuum. From life sciences research discovery efforts, through drug development, and into clinical research, our comprehensive range of products are designed to support your goals. When a standard catalog product does not meet your needs, talk to us about custom solutions; we can help
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