Description:

ThecytochromeP-4504(CYP4)familyconsistsofelevensub-familieswhichencodeconstitutiveandinducIBLeisoenzymesexpressedinbothmammalsandinvertebrates.TheCYP4A1,4A2and4A3genesareexpressedconstitutivelyinratliverandkidney,andtheirexpressionisstimulatedbyperoxisomeproliferatorssuchasthehypolipidaemicdrugclofibrate(Cat.#EI-160),althoughCYP4A1hasalsobeenshowntobehormonallyregulated.CYP4expressioninducedbyclofibrateisduetotranscription,possiblymediatedbyaperoxisomeproliferator-activatedreceptor(PPAR).TheantiserumwasraisedtotheC-terminalpeptideofratCYP4A1(Cat.#CP0341),butcrossreactswithratCYP4A2andCYP4A3.

ProductSpecification:

AlternativeName:	CYP4A1,CYP4A2andCYP4A3
Host:	Sheep
Immunogen:	SyntheticpeptidecorrespondingtoaportionofC-terminalratCYP4A1.
UniProtID:	P08516(CYP4A1),P20816(CYP4A2),P20817(CYP4A3)
Speciesreactivity:	Rat
Specificity:	RecognizesratCYP4A1,CYP4A2andCYP4A3.
Applications:	IHC,WB
Shipping:	ShippedonBlueIce
LongTermStorage:	-20°C

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