酶科学/CFTR单克隆抗体（CF3）/ALX-804-214-R100/100µ；L
商品编号：
ALX-804-214-R100
品牌：
enzolifesciences
市场价：
¥11800.00
美元价：
7080.00
产品分类：
外泌体研究
公司分类：
exosome_research
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product Specification:
| Alternative Name: | Cystic fibrosis transmembrane conductance regulator, ABCC7 |
| Clone: | CF3 |
| Host: | Mouse |
| Isotype: | IgM |
| Immunogen: | Synthetic peptide corresponding to aa 103-117(G103RIIASYDPDNKEER117) in the first extracellular loop of human and rabbit CFTR (cystic fibrosis transmembrane conductance regulator). This sequence is highly conserved in mouse, sheep, bovine and Xenopus laevis CFTR. |
| UniProt ID: | P13569 |
| Species reactivity: | Human, Mouse |
| Crossreactivity: | Cross-reacts with related proteins in mouse cell line Heb7a that doesn not contain CFTR mRNA. |
| Applications: | ICC, IP, WB |
| Recommended Dilutions/Conditions: | Immunocytochemistry (1:500; staining of CFTR in mouse epithelial cells results in cell surface staining, consistent with localization at the plasma membrane. Antibody also detects one or more immunologically related proteins in murine cell line Heb7a that does not contain CFTR mRNA.) Western Blot (1:500) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of ~170kDa by Western blot. Functional Application: inhibits epithelial uptake of S. typhi in some mouse cell lines. |
| Formulation: | Liquid. Diluted ascites containing 0.05% sodium azide. |
| Handling: | Avoid freeze/thaw cycles. |
| Shipping: | Shipped on Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | Cystic Fibrosis (CF) is a common lethal genetic disease caused by mutations of the gene coding for the cystic fibrosis transmembrane conductance factor, a cAMP regulated chloride channel. Approximately 70% of all CF cases share the deletion of a phenylalanine at position 508 (δ F508) which results in abnormal chloride transport. Since the CF mutation is lethal, most often by lung and liver disease, it raises the question of why this genetic disease remains as common as it is. One possible explanation is that Salmonella typhi has been shown to use CFTR to enter intestinal epithelial cells and that delta F508 heterozygote and homozygote mice showed 86% and 100% reductions in S. typhi intestinal submucosal uptake. |
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Company Profile
Name:Enzo Life SciencesCategory:Corporation/Limited Liability CompanyTrade Category: ManufacturerRegistered Time: 1996Registered Capital: Above US$100 MillionLegal Representative:Employees:Address: TaksimWebsite: http://www.enzolifesciences.comProduct/Service: chemicals
Our breadth of scientific expertise coupled with unique technology platforms give us the flexibility to drive innovation throughout the entire research continuum. From life sciences research discovery efforts, through drug development, and into clinical research, our comprehensive range of products are designed to support your goals. When a standard catalog product does not meet your needs, talk to us about custom solutions; we can help
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