酶学/Ca2+传感受体多克隆抗体/ALX-210-143-R100/100µ；L
商品编号：
ALX-210-143-R100
品牌：
enzolifesciences
市场价：
¥11800.00
美元价：
7080.00
产品分类：
外泌体研究
公司分类：
exosome_research
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product Specification:
| Alternative Name: | CASR |
| Host: | Rabbit |
| Immunogen: | Synthetic peptide corresponding to aa 12-27 (A12LAWHSSAYGPDQRAQ27) of rat CASR (Ca2+-sensing receptor). |
| UniProt ID: | P48442 |
| Species reactivity: | Human, Rat |
| Applications: | WB |
| Recommended Dilutions/Conditions: | Western Blot (1:100) |
| Application Notes: | Detects a band of ~120kDa by Western blot. |
| Purity Detail: | Epitope-affinity purified. |
| Formulation: | Liquid. In PBS containing 0.05% sodium azide. |
| Handling: | Avoid freeze/thaw cycles. |
| Shipping: | Shipped on Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | The calcium sensing receptor (CASR) has been shown to play a major role in regulating parathyroid hormone secretion and subsequently influencing the calcium concentration of extracellular fluids. Based on sequence analysis of cDNA clones it appears that the CASR is similar to the 7-transmembrane-domain G-protein-coupled receptor superfamily. Changes in extracellular calcium are thought to modulate a balance between proliferation and differentiation in a variety of cell types. In normal primary keratinocytes and breast epithelial cells, proliferation is inhibited and elevated extracellular calcium levels trigger differentiation. Malignant transformations of these cell types are accompanied by a loss of responsiveness to the anti-proliferative effects of elevated extracellular calcium. Several disorders of calcium homeostasis have been linked to mutations in the CASR. These include familial hypocalciuric hypercalcemia (FHH), neonatal severe hyperparathyroidism (NSHPT), and autosomal dominant hypocalemia (ADHypo). |
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Company Profile
Name:Enzo Life SciencesCategory:Corporation/Limited Liability CompanyTrade Category: ManufacturerRegistered Time: 1996Registered Capital: Above US$100 MillionLegal Representative:Employees:Address: TaksimWebsite: http://www.enzolifesciences.comProduct/Service: chemicals
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