酶科学/BAP31单克隆抗体(A1/182)/ALX-804-601-C100/100µ;G
商品编号:
ALX-804-601-C100
品牌:
enzolifesciences
市场价:
¥6680.00
美元价:
4008.00
产品分类:
外泌体研究
公司分类:
exosome_research
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Product Specification:
Alternative Name: | p28 BAP31, B cell receptor-associated protein BAP31, BCR-associated protein BAP31, CDM, DXS1357E, 6C6-AG tumor-associated antigen, BCAP31 |
Clone: | A1/182 |
Host: | Mouse |
Isotype: | IgG2a |
Immunogen: | BAP31 (BCR associated protein BAP031) from Vero monkey cells. |
UniProt ID: | P51572 (human) |
Species reactivity: | Human Monkey |
Applications: | ELISA, Flow Cytometry, ICC, IHC (FS), IP, WB |
Recommended Dilutions/Conditions: | Immunocytochemistry (1:1,000) Immunoprecipitation (2µl) Western Blot (1:1,000) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
Formulation: | Lyophilized. Protein G-affinity purified and gel filtrated (FPLC). |
Reconstitution: | Reconstitute with 100µl PBS containing 0.1% sodium azide. |
Handling: | Avoid freeze/thaw cycles. |
Shipping: | Shipped on Blue Ice |
Long Term Storage: | -20°C |
Scientific Background: | BAP31 (B cell receptor-associated protein 31) is an integral protein of the ER membrane that forms a large hetero-oligomeric complex with the related BAP29. The cytosolic domain of BAP31 contains two identical caspase recognition sites that are preferentially cleaved by initiator caspases, including caspase-8. After activation of cell surface death receptors, human BAP31 is cleaved into a membrane-embedded fragment called p20, which induces apoptosis when expressed ectopically. The p20 fragment can mediate Ca2+-dependent apoptotic cross-talk between the ER and mitochondria, stimulating cytochrome c release. In addition to its role in apoptosis, BAP31 is a component of the ER quality control compartment and functions as a cargo receptor for ER export of transmembrane proteins such as cellubrevin, MHC class I molecules, and cytochrome P450 2C2. |
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Company Profile
Name:Enzo Life SciencesCategory:Corporation/Limited Liability CompanyTrade Category: ManufacturerRegistered Time: 1996Registered Capital: Above US$100 MillionLegal Representative:Employees:Address: TaksimWebsite: http://www.enzolifesciences.comProduct/Service: chemicals
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