酶学/脱嘌呤/脱嘧啶核酸内切酶（人）单克隆抗体（13B 8E5C2）/ALX-804-213-R100/100µ；L
商品编号：
ALX-804-213-R100
品牌：
enzolifesciences
市场价：
¥12260.00
美元价：
7356.00
产品分类：
外泌体研究
公司分类：
exosome_research
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
ProductSpecification:
| AlternativeName: | HAP1,APEX,APE1,Ref-1 |
| Clone: | 13B8E5C2 |
| Host: | Mouse |
| Isotype: | IgG2a |
| Immunogen: | RecombinanthumanAPE1(apurinic/apyrimidinicendonuclease). |
| UniProtID: | P27695 |
| Speciesreactivity: | Human |
| Applications: | IHC(PS),IP,WB |
| RecommendedDilutions/Conditions: | Immunohistochemistry(paraffinsections,1:100) WesternBlot(1:1,000) Suggesteddilutions/conditionsmaynotbeavailableforallapplications. Optimalconditionsmustbedeterminedindividuallyforeachapplication. |
| ApplicationNotes: | Detectsabandof~37kDabyWesternblot. |
| Formulation: | Liquid.InPBScontaining0.05%sodiumazide. |
| Handling: | Avoidfreeze/thawcycles. |
| Shipping: | ShippedonBlueIce |
| LongTermStorage: | -20°C |
| ScientificBackground: | Mammalianapurinic/apyrimidinic(AP)endonuclease(APE1;APEX;HAP1;Ref-1)isamultifunctional,bipartiteenzymethatbelongstotheclassIIAPendonucleasesandthatplaysanimportantroleinnumerous,cellularfunctions,likerepairingabasicsites(lossofpurineorpyrimidinebase)inDNA,regulatingtheredoxstateofotherproteinsthatplayrolesinoxidativesignalling,transcriptionfactorregulation(Fos,Jun,NF-κB,Myb,HIF-1α,CREB,Pac),cellcyclecontrol(p53)andapoptosis.APE1initiatestheDNAbaseexcisionrepair(BER)bycleavingtheDNAimmediatelyadjacenttothe5’ofanAPsitetoproduceahydroxylgroupatthe3’terminusofanunmodifiednucleotideupstreamofthenickanda5’-deoxyribosephosphatemoietydownstream.TheproductofAPE1isfurtherprocessedbyDNApolymeraseβtorelease5’-deoxyribosephosphatewithitsintrinsiclyaseactivity.ThenickedDNAisthensealedbyDNAligaseIorDNAligaseIII/XRCC1tocompletethisrepairprocess.InadditiontotheAPendonucleaseactivity,APE1alsopossessesa3’-5’DNAexonucleaseactivity,a3’-phosphodiesteraseactivity,a3’-phosphataseactivity,andaRNaseHactivity.IthasbeenshownthatAPE1iscapableofexcisionL-configurationdeoxyribonucleosideanalogsfromthe3’terminiofDNA.HumanAPE1geneislocatedonchromosome14q11.2-12. |
品牌介绍
Product categoriesPharmaceuticals And Biochemic
CAS 6090-98-8
conduritol F
CAS 20544-37-0
2,4,8,10-Tetraoxa-3,
CAS 135564-23-7
Benzaldehyde, 4-amin
CAS 34169-62-5
2-Naphthalenesulfoni
CAS 6305-52-8
2-Butyldecahydronaph
CAS 10074-13-2
1,3-Benzenedimethane
CAS 84434-05-9
Acetic acid,2-[(9-ox
CAS 104748-51-8
Avilamycin K
CAS 5539-08-2
Ergoline-8-carboxyli
CAS 1242-56-4
Androst-1-en-3-one,1
CAS 52978-30-0
(1R,2R,3E,5E,15E,17E
CAS 24471-48-5
2-Pyrenemethanol
CAS 39325-01-4
Picibanil
CAS 244290-68-4
Quinolinium, 7-[(die
CAS 80584-90-3
1H-Benzotriazole-1-m
CAS 65193-87-5
Butanoic acid, 3-oxo
CAS 3563-92-6
Zylofuramine
CAS 24979-74-6
Phenol,4-ethenyl-, p
CAS 1067-48-7
1-Pentanamine, 5-(tr
CAS 62886-59-3
Sephadex-CM C-25,ion
View all products
Company Profile
Name:Enzo Life SciencesCategory:Corporation/Limited Liability CompanyTrade Category: ManufacturerRegistered Time: 1996Registered Capital: Above US$100 MillionLegal Representative:Employees:Address: TaksimWebsite: http://www.enzolifesciences.comProduct/Service: chemicals
Our breadth of scientific expertise coupled with unique technology platforms give us the flexibility to drive innovation throughout the entire research continuum. From life sciences research discovery efforts, through drug development, and into clinical research, our comprehensive range of products are designed to support your goals. When a standard catalog product does not meet your needs, talk to us about custom solutions; we can help
品牌分类
抗体
联络我们
